• Corpus ID: 29475504

Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease.

  title={Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease.},
  author={Qianzhen Li and Liang-wan Chen and Dao-zhong Chen and Xi-jie Wu and Meifang Chen},
  journal={American journal of translational research},
  volume={7 2},
Genetic variants in pre-microRNA (miRNA) genes or the 3'UTR of miRNA target genes could influence miRNA-mediated regulation of gene expression and thus contribute to the susceptibility and prognosis of human diseases. This study aimed to investigate the effect of 6 miRNA-related polymorphisms (miR-149 rs71428439, miR-146a rs2910164, miR-499 rs3746444, miR-423 rs6505162, miR-4513 rs2168518, and FABP2 rs11724758) on prognosis in 1004 patients with angiographic coronary artery disease (CAD). We… 

Figures and Tables from this paper

Associations of MicroRNA Polymorphisms (miR-146a, miR-196a2, and miR-499) with the Risk of Hypertension in the Korean Population.

It is suggested that the variant of miR-146aC>G polymorphism and allelic combinations, at least in Koreans, affect susceptibility to hypertension.

Genetic Variants of MIR27A, MIR196A2 May Impact the Risk for the Onset of Coronary Artery Disease in the Pakistani Population

The variants rs895819 and rs11614913 are the susceptibility factors for CAD.

Associations of MicroRNA Polymorphisms (miR-146a, miR-196a2, and miR-499) with the Risk of Hypertension in the Korean Population

This study investigated the associations of three miR gene polymorphisms with the risk of hypertension in Korean patients and found significant differences in the genotype distributions of the miR-146aC>G polymorphism between the hypertensive patients and controls with the GG genotype.

Incidence of MicroR-4513C/T Gene Variability in Coronary Artery Disease- A case-Control Study.

  • R. MirC. Jha S. Chahal
  • Biology, Medicine
    Endocrine, metabolic & immune disorders drug targets
  • 2019
The study found that the miR-4513 CT genotype and T allele are associated with increased risk of developing CAD, and studies with larger sample sizes are necessary to confirm this result.

Two Single Nucleotide Polymorphisms (rs2431697 and rs2910164) of miR-146a Are Associated with Risk of Coronary Artery Disease

It is found that the T allele of rs2431697 was a risk factor of CAD in the Chinese population, and it is demonstrated that the G allele ofrs2910164 decreased the susceptibility of CAD.

Association of MIR-499a expression and seed region variant (rs3746444) with cardiovascular disease in Egyptian patients

Circulating miR-499a levels could be a useful biomarker, discriminating acute MI within 12 hours from healthy subjects, and its variant rs3746444 A/G is associated with increased susceptibility to acute MI and CAD in Egyptian population.

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

The SNPs in miRNA genes that have been associated with diabetes and atherosclerotic cardiovascular disease in different populations are discussed and the potential underlining mechanisms through which these SNPs increase the risk of developing these diseases are discussed.

miR-3188 (rs7247237-C>T) Single-Nucleotide Polymorphism Is Associated With the Incidence of Vascular Complications in Chinese Patients With Type 2 Diabetes.

Mechanistic analyses indicate that miR-3188 (rs7247237-T) polymorphism inhibited its own expression and upregulated the expression of gstm1 and trib3, which impairs NO production in human endothelial cells through inactivating AKT/eNOS signal transduction pathway.

Seed sequence polymorphism rs2168518 and allele-specific target gene regulation of hsa-miR-4513

Remarkably, multiple allele-specific target genes identified are linked via text retrieval to several phenotypes previously reported to be associated with hsa-miR-4513, which could give rise to therapeutic applications targeting this miRNA.



Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population.

Findings indicate thatmiR-499 rs3746444 and miR-146a rs2910164 may represent novel markers of MI susceptibility.

A Genetic Variant in the Seed Region of miR‐4513 Shows Pleiotropic Effects on Lipid and Glucose Homeostasis, Blood Pressure, and Coronary Artery Disease

It is found that rs2168518:G>A, a seed region variant of miR‐4513, associates with fasting glucose, low‐density lipoprotein–cholesterol, total cholesterol, systolic and diastolic blood pressure, and risk of coronary artery disease.

Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease

Findings strongly implicate the functional miRNAs polymorphisms of hsa-mir-196a2 and hsa -mir-499 genes may modulate the occurrence or prognosis in Chinese CAD.

Hsa‐mir‐27a genetic variant contributes to gastric cancer susceptibility through affecting miR‐27a and target gene expression

It is shown that a common polymorphism (rs895819) in hsa‐mir‐27a, by modulating miR‐ 27a and ZBTB10 levels, acted as an important factor of the gastric cancer susceptibility.

Prognostic role of microRNA polymorphisms in patients with advanced esophageal squamous cell carcinoma receiving platinum-based chemotherapy

Findings indicate that miRNA polymorphisms may predict prognosis in advanced esophageal squamous cell carcinoma patients receiving platinum-based chemotherapy.

Genetic Polymorphisms in Pre-microRNAs and Risk of Ischemic Stroke in a Chinese Population

Evidence is provided that hsa-mir-499/rs3746444 A/G polymorphism might be associated with a significantly increased risk of ischemic stroke in a Chinese population, indicating that the common genetic polymorphism in pre-microRNAs contributed to the pathogenesis of isChemic stroke.

Association of miR-146a rs2910164 with childhood IgA nephropathy

Results indicated that rs2910164 may affect the susceptibility and severity of pediatric IgAN, and further studies are needed to validate these findings.

Prognostic value of miR-221-3p, miR-342-3p and miR-491-5p expression in colon cancer.

The results suggest that the three-miRNA signature may help doctors better predict prognosis and guide treatment decisions for colon cancer.

Genetic variants of miRNA sequences and non-small cell lung cancer survival.

A systematic survey of common pre-miRNA SNPs and their surrounding regions found that the rs11614913 SNP in hsa-mir-196a2 was associated with survival in individuals with non-small cell lung cancer, and may be a prognostic biomarker for NSCLC.

Age-related changes in microRNA levels in serum

The results suggest that circulating miRNAs may be a biological marker of aging and could also be important for regulating longevity and Identification of stable miRNA biomarkers in serum could have great potential as a noninvasive diagnostic tool as well as enhance the understanding of physiological changes that occur with age.