Influence of metallothionein-1 localization on its function.

  title={Influence of metallothionein-1 localization on its function.},
  author={Marilyne Levadoux-Martin and John E. Hesketh and John H. Beattie and Heather M. Wallace},
  journal={The Biochemical journal},
  volume={355 Pt 2},
Metallothioneins (MTs) have a major role to play in metal metabolism, and may also protect DNA against oxidative damage. MT protein has been found localized in the nucleus during S-phase. The mRNA encoding the MT-1 isoform has a perinuclear localization, and is associated with the cytoskeleton; this targeting, due to signals within the 3'-untranslated region (3'-UTR), facilitates nuclear localization of MT-1 during S-phase [Levadoux, Mahon, Beattie, Wallace and Hesketh (1999) J. Biol. Chem. 274… CONTINUE READING