Influence of metabolic network structure and function on enzyme evolution

  title={Influence of metabolic network structure and function on enzyme evolution},
  author={Dennis Vitkup and Peter V. Kharchenko and Andreas Wagner},
  journal={Genome Biology},
  pages={R39 - R39}
Most studies of molecular evolution are focused on individual genes and proteins. However, understanding the design principles and evolutionary properties of molecular networks requires a system-wide perspective. In the present work we connect molecular evolution on the gene level with system properties of a cellular metabolic network. In contrast to protein interaction networks, where several previous studies investigated the molecular evolution of proteins, metabolic networks have a… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 87 extracted citations


Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…