Influence of metabolic network structure and function on enzyme evolution

@article{Vitkup2005InfluenceOM,
  title={Influence of metabolic network structure and function on enzyme evolution},
  author={Dennis Vitkup and Peter V. Kharchenko and Andreas Wagner},
  journal={Genome Biology},
  year={2005},
  volume={7},
  pages={R39 - R39}
}
Most studies of molecular evolution are focused on individual genes and proteins. However, understanding the design principles and evolutionary properties of molecular networks requires a system-wide perspective. In the present work we connect molecular evolution on the gene level with system properties of a cellular metabolic network. In contrast to protein interaction networks, where several previous studies investigated the molecular evolution of proteins, metabolic networks have a… CONTINUE READING

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