Influence of membrane surface potential and of net charge on aminoglycoside binding to the organ of Corti of guinea pigs.

Abstract

Gentamicin binding to homogenates of the organ of Corti of guinea pigs was investigated by altering the magnitude of the membrane surface potential and by testing the potencies of various polyamines and polyamino acids with different numbers of amino groups and different net charge to inhibit or displace bound gentamicin. Diminishing or increasing the ionic… (More)

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@article{Huy1990InfluenceOM, title={Influence of membrane surface potential and of net charge on aminoglycoside binding to the organ of Corti of guinea pigs.}, author={Patrice Tran Ba Huy and Dominique Deffrennes}, journal={ORL; journal for oto-rhino-laryngology and its related specialties}, year={1990}, volume={52 2}, pages={121-6} }