Influence of marketed herbal menopause preparations on MCF-7 cell proliferation
@article{Bodinet2004InfluenceOM, title={Influence of marketed herbal menopause preparations on MCF-7 cell proliferation}, author={Cornelia Bodinet and John V Freudenstein}, journal={Menopause}, year={2004}, volume={11}, pages={281-289} }
Objective:Given the increasing use of alternative menopause treatments, we evaluated the effect of several herbal preparations used for menopause relief on the proliferation of estrogen-sensitive breast cancer cells (MCF-7) as a means of assessing appropriateness for use in women at risk for estrogen-sensitive breast cancer. Design:An MCF-7 cell culture model, as described previously, 1 was used to evaluate the estrogen-agonist and -antagonist activity of commercially available herbal menopause…
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References
SHOWING 1-10 OF 39 REFERENCES
Influence of Cimicifuga Racemosa on the Proliferation of Estrogen Receptor-Positive Human Breast Cancer Cells
- Biology, MedicineBreast Cancer Research and Treatment
- 2004
Data that suggest a non-estrogenic, or estrogen-antagonistic effect of CR on human breast cancer cells lead to the conclusion that CR treatment may be a safe, natural remedy for menopausal symptoms in breast cancer.
Soy for breast cancer survivors: a critical review of the literature.
- BiologyThe Journal of nutrition
- 2001
Overall, the data are not impressive that the adult consumption of soy affects the risk of developing breast cancer or that soy consumption affects the survival of breast cancer patients, so it seems reasonable for Breast cancer patients to continue to use soy products.
Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro.
- BiologyNutrition and cancer
- 1997
The results reveal that genistein is unique among the flavonoids tested, in that it has potent estrogen agonist and cell growth-inhibitory actions over a physiologically relevant concentration range.
Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.
- Biology, MedicineJournal of agricultural and food chemistry
- 2001
Genistein was found to be the most effective of four red clover isoflavones tested in the above in vitro assays, suggesting a potential use for some dietary supplements, ingested by human beings, in the treatment of menopausal symptoms.
Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo.
- BiologyCancer research
- 1998
Dietary genistein can act as an estrogen agonist in vivo and in vitro, resulting in the proliferation of cultured human breast cancer cells (MCF-7) and the induction of pS2 gene expression.
Effects of Soy Phytoestrogens Genistein and Daidzein on Breast Cancer Growth
- Medicine
- 2001
Genistein and daidzein may stimulate existing breast tumor growth and antagonize the effects of tamoxifen, which should be aware of the risks of potential tumor growth when taking soy products.
Effects of soy phytoestrogens genistein and daidzein on breast cancer growth.
- MedicineThe Annals of pharmacotherapy
- 2001
Genistein and daidzein may stimulate existing breast tumor growth and antagonize the effects of tamoxifen and women with current or past breast cancer should be aware of the risks of potential tumor growth when taking soy products.
Estrogen and Progestin Bioactivity of Foods, Herbs, and Spices
- Medicine, BiologyProceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
- 1998
It is demonstrated that many of the commonly consumed foods, herbs, and spices contain phytoestrogens and phytoprogestins that act as agonists and antagonists in Vivo.
Growth inhibition of human breast cancer cells by herbs and phytoestrogens.
- Biology, MedicineOncology reports
- 1999
Epidemiologic studies have suggested that consumption of phytoestrogen-rich foods may protect against breast cancer, and phytoestrogens such as genistein have been reported to both inhibit and…
Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extract.
- Biology, MedicineCancer research
- 2002
The lack of mammary tumor-stimulating effects of this extract is of great significance in establishing the safety of CR extracts for treatment of menopausal symptoms in women with a history of breast cancer in which hormone-replacement therapy is contraindicated.