Influence of mannose-binding lectin on HIV infection and tuberculosis in a Western-European population.

@article{GarcaLaorden2006InfluenceOM,
  title={Influence of mannose-binding lectin on HIV infection and tuberculosis in a Western-European population.},
  author={M Isabel Garc{\'i}a-Laorden and Maria Jos{\'e} Mellado Pena and Jos{\'e} A. Caminero and Ayoze Garc{\'i}a-Saavedra and Mar{\'i}a Isolina Campos-Herrero and Araceli Caballero and Carlos Rodr{\'i}guez-Gallego},
  journal={Molecular immunology},
  year={2006},
  volume={43 14},
  pages={2143-50}
}
Mannose-binding lectin (MBL) is a serum lectin that mediates phagocytosis and activates complement. Its deficiency has been associated with increased susceptibility to infectious diseases, mainly in childhood. However, non-producer mbl-2 alleles are common in most populations, suggesting a selective advantage of these alleles. We have analysed the association of mbl-2 structural and promoter polymorphisms with HIV infection and tuberculosis (TBC) in a white Spanish population, including 615 HIV… CONTINUE READING