Influence of malonyl-CoA and palmitate concentration on rate of palmitate oxidation in rat muscle.

@article{Merrill1998InfluenceOM,
  title={Influence of malonyl-CoA and palmitate concentration on rate of palmitate oxidation in rat muscle.},
  author={Gary F. Merrill and E J Kurth and Blake B. Rasmussen and William W. Winder},
  journal={Journal of applied physiology},
  year={1998},
  volume={85 5},
  pages={
          1909-14
        }
}
5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR) is taken up by perfused skeletal muscle and phosphorylated to form 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuraosyl-5'-monopho sph ate (analog of 5'-AMP) with consequent activation of AMP-activated protein kinase, phosphorylation of acetyl-CoA carboxylase, decrease in malonyl-CoA, and increase in fatty acid oxidation. This study was designed to determine the effect of increasing levels of palmitate on the rate of fatty acid… 

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