Influence of mTOR in energy and metabolic homeostasis.

@article{Haissaguerre2014InfluenceOM,
  title={Influence of mTOR in energy and metabolic homeostasis.},
  author={Magalie Haissaguerre and Nicolas Saucisse and Daniela Cota},
  journal={Molecular and cellular endocrinology},
  year={2014},
  volume={397 1-2},
  pages={67-77}
}
The mechanistic (or mammalian) target of rapamycin couples a variety of different environmental signals, including nutrients and hormones, with the regulation of several energy-demanding cellular functions, spanning from protein and lipid synthesis to mitochondrial activity and cytoskeleton dynamics. mTOR forms two distinct protein complexes in cells, mTORC1 and mTORC2. This review focuses on recent advances made in understanding the roles played by these two complexes in the regulation of… CONTINUE READING
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