Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.

  title={Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.},
  author={Vojo Vukovic and Ian F. Tannock},
  journal={British Journal of Cancer},
  pages={1167 - 1172}
The extracellular pH (pHe) of solid tumours is often lower than in normal tissues, and this may influence the uptake and/or activity of anti-cancer drugs. The cytotoxicity of mitoxantrone, paclitaxel and topotecan was therefore assessed at low pHe and after manipulation of intracellular pH (pHi) in murine EMT6 and in human MGH-U1 cells. The cytotoxic efficacy of all three agents was reduced at pHe 6.5 as compared with pHe 7.4. The ionophore nigericin and inhibitors of membrane-based ion… CONTINUE READING


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