Influence of local environment on the differentiation of neural stem cells engrafted onto the injured spinal cord.

@article{RicciVitiani2006InfluenceOL,
  title={Influence of local environment on the differentiation of neural stem cells engrafted onto the injured spinal cord.},
  author={Lucia Ricci-Vitiani and Patrizia Casalbore and Giovanna Petrucci and Liverana Lauretti and N. Montano and Luigi Maria Larocca and Maria Laura Falchetti and Dario Giuseppe Lombardi and Valeria Di Giorgio Gerevini and Carlo Cenciarelli and Quintino Giorgio D'Alessandris and Eduardo Fern{\'a}ndez and Ruggero de Maria and G Maira and Cesare Peschle and Eugenio Agostino Parati and Roberto Pallini},
  journal={Neurological research},
  year={2006},
  volume={28 5},
  pages={488-92}
}
OBJECTIVES In vitro, neural stem cells (NSCs) proliferate as undifferentiated spheroids and differentiate into neurons, astrocytes and oligodendrocytes. These features make NSCs suitable for spinal cord (SC) reconstruction. However, in vivo experiments have demonstrated that in the injured SC transplanted NSCs either remain undifferentiated or differentiate into the astrocytic phenotype. The microenvironment of the injured SC is believed to play a crucial role in driving the differentiation of… CONTINUE READING
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