Influence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofluorene, ultraviolet light, or transforming growth factor beta 1.

@article{Worner1996InfluenceOL,
  title={Influence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofluorene, ultraviolet light, or transforming growth factor beta 1.},
  author={Wayne Worner and Dieter Schrenk},
  journal={Cancer research},
  year={1996},
  volume={56 6},
  pages={1272-8}
}
DNA damage is recognized widely as a cause of programmed cell death (apoptosis), aimed at eliminating cells bearing genotoxic lesions. Therefore, inhibition of DNA damage-induced apoptosis may play an important role in carcinogenesis and has been suggested as a mechanism of action of tumor-promoting agents. In the present study, the effects of treatment with UV light or the carcinogenic aromatic amine 2-acetylaminofluorene (2-AAF) on apoptosis were studied in rat hepatocytes in primary culture… CONTINUE READING
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