Influence of lipid components on gene delivery by polycation liposomes: Transfection efficiency, intracellular kinetics and in vivo tumor inhibition.

@article{Chen2012InfluenceOL,
  title={Influence of lipid components on gene delivery by polycation liposomes: Transfection efficiency, intracellular kinetics and in vivo tumor inhibition.},
  author={Jinliang Chen and Xiao-yi Sun and Zhenwei Yu and Jianqing Gao and Wenquan Liang},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={422 1-2},
  pages={510-5}
}
Transfection efficiency of non-viral gene vectors is influenced by many factors, including chemical makeup, cellular uptake pathway and intracellular delivery. To investigate the effect of lipid saturation on transfection efficiency of polycation liposomes (PCLs), a soybean phospholipids (SPL), egg phospholipids (EPL) and hydrogenated soybean phosphatidylcholine (HSPC) series was used to prepare PCLs. Testing these PCLs in a luciferase assay indicated that with increasing saturation (SPL<EPL… CONTINUE READING

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