Corpus ID: 12092490

Influence of limonene and laurocapram on percutaneous absorption of nonsteroidal anti-inflammatory drugs.

@article{Pborsk1992InfluenceOL,
  title={Influence of limonene and laurocapram on percutaneous absorption of nonsteroidal anti-inflammatory drugs.},
  author={Jan Př{\'i}borsk{\'y} and Kozo Takayama and Yasuko Obata and Zuzana Př{\'i}borsk{\'a} and Tsuneji Nagai},
  journal={Arzneimittel-Forschung},
  year={1992},
  volume={42 2},
  pages={
          116-9
        }
}
  • Jan Příborský, Kozo Takayama, +2 authors Tsuneji Nagai
  • Published in Arzneimittel-Forschung 1992
  • Chemistry, Medicine
  • The promoting effect of cyclic monoterpenes, 1% limonene (CAS 5989-27-5) and 1% cineole (CAS 470-82-6), on percutaneous absorption of nonsteroidal anti-inflammatory drugs was investigated in the rats. Compared with 1% laurocapram, drug absorption from the gel ointments was significantly more enhanced by addition of 1% limonene, while without any enhancer only ibuprofen penetrated across the skin in the limited amount. When using formulation with propylene glycol or 50% propylene glycolethanol… CONTINUE READING

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