Influence of kidney function on risk of supratherapeutic international normalized ratio-related hemorrhage in warfarin users: a prospective cohort study.

@article{Limdi2015InfluenceOK,
  title={Influence of kidney function on risk of supratherapeutic international normalized ratio-related hemorrhage in warfarin users: a prospective cohort study.},
  author={Nita A. Limdi and Thomas D Nolin and Sarah L. Booth and Amanda Centi and M. A. Barbosa Marques and Michael R. Crowley and Michael A Allon and T. Mark Beasley},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2015},
  volume={65 5},
  pages={
          701-9
        }
}
BACKGROUND Anticoagulation management is difficult in chronic kidney disease, with frequent supratherapeutic international normalized ratios (INRs ≥ 4) increasing hemorrhagic risk. We evaluated whether the interaction of INR and lower estimated glomerular filtration rate (eGFR) increases hemorrhage risk and whether patients with lower eGFRs experience slower anticoagulation reversal. STUDY DESIGN Prospective cohort study. SETTING & PARTICIPANTS Warfarin pharmacogenetics cohort (1,273 long… CONTINUE READING
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