Influence of isoflurane concentration and hypoxia on functional magnetic resonance imaging for the detection of bicuculline-induced neuronal activation.

@article{Abo2004InfluenceOI,
  title={Influence of isoflurane concentration and hypoxia on functional magnetic resonance imaging for the detection of bicuculline-induced neuronal activation.},
  author={Masahiro Abo and Masahiko Suzuki and Atushi Senoo and Satoshi Miyano and Hideki Yamauchi and Kyozo Yonemoto and Shu Watanabe and Lars Edstr{\"o}m},
  journal={Neuro-Signals},
  year={2004},
  volume={13 3},
  pages={144-9}
}
Our present study shows that transient changes in relative cerebral blood volume (rCBV) induced by stimulation with bicuculline under six different conditions of anesthesia can be detected with high spatial resolution functional magnetic resonance imaging (fMRI). Bicuculline was administered at a low dose to induce neural activation, and no seizure activity was noted. Of the six conditions, the maximal reaction to bicuculline was observed under 1.5% isoflurane in 60% nitrogen and 40% oxygen… CONTINUE READING