Influence of ionic strength on contractile force and energy consumption of skinned fibers from mammalian and crustacean striated muscle.

@article{Godt1993InfluenceOI,
  title={Influence of ionic strength on contractile force and energy consumption of skinned fibers from mammalian and crustacean striated muscle.},
  author={R. Godt and R. Fogaça and M. Andrews and T. Nosek},
  journal={Advances in experimental medicine and biology},
  year={1993},
  volume={332},
  pages={
          763-73; discussion 773-4
        }
}
Increased ionic strength decreases maximal calcium-activated force (Fmax) of skinned muscle fibers via mechanisms that are incompletely understood. In detergent-skinned fibers from either rabbit (psoas) or lobster (leg or abdomen), Fmax in KCl-containing solutions was less than in potassium methanesulfonate (KMeSO3), which we showed previously was the least deleterious salt for adjusting ionic strength. In either salt, lobster fibers were considerably less sensitive to elevated ionic strength… Expand
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The data indicate that increased ionic strength per sc decreases Fmax, probably by destabilizing the cross-bridge structure in addition to increasing electrostatic shielding of actomyosin interactions. Expand
Tension in Skinned Frog Muscle Fibers in Solutions of Varying Ionic Strength and Neutral Salt Composition
The maximal calcium-activated isometric tension produced by a skinned frog single muscle fiber falls off as the ionic strength of the solution bathing this fiber is elevated declining to zero nearExpand
Ionic Strength and the Contraction Kinetics of Skinned Muscle Fibers
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The results suggest that in fibers activated at low ionic strength some of the cross bridges that are formed are abnormal in the sense that they retard shortening and persist in relaxing solution. Expand
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It is demonstrated that the ionic strength affects the tension-generating capacity of the muscle as it affects the chemo-mechanical transform of excitation-contraction coupling and it is further demonstrated that interfilament spacing changes encountered during shortening and with variation in the osmotic strength have no effect upon the tensions of muscle. Expand
THE EFFECTS OF OSMOREGULATORY SOLUTES ON TENSION GENERATION BY DOGFISH SKINNED MUSCLE FIBRES
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The effects of osmoregulatory solutes on tension generation in skinned fibres isolated from dogfish myotomal muscle have been investigated and it is found that TMAO acts as a general protein stabilizer and can offset the effects of urea on enzyme Km and maximal velocity in vitro. Expand
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TLDR
Both in vitro binding and the effect of overlap on rapid stiffness measurements in fibers suggest that cross-bridges are attached to actin in relaxed muscle at low ionic strength. Expand
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The pCa required for 50% maximal force (pCa50) was inversely proportional to absolute temperature, and the shift was consistent with a Gibbs free energy change of binding (delta G) of about -7.8 kcal/mol. Expand
Effect of changing the composition of the bathing solution upon the isometric tension—pCa relationship in bundles of crustacean myofibrils
1. The relative isometric tension—pCa relationship has been determined for isolated bundles of barnacle myofibrils under a variety of ionic conditions using [Ca2+]-buffered solutions which alsoExpand
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