Influence of ion-pair-formation on the pharmacokinetic properties of drugs. Part 4: Influence of hexylsalicylic acid on the pharmacokinetics of bretylium.

Abstract

Based on in vitro results it was found that the pharmacokinetic parameters of the hydrophilic drug bretylium (2) can be influenced by an ion-pair-formation with the lipophilic hexylsalicyclic acid (1). After simultaneous i.v. application of 1 and 2 on rabbits a significant increase of the AUC of 2 was observed. Under these conditions a marked increase of… (More)

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Cite this paper

@article{Neubert1988InfluenceOI, title={Influence of ion-pair-formation on the pharmacokinetic properties of drugs. Part 4: Influence of hexylsalicylic acid on the pharmacokinetics of bretylium.}, author={Reinhard H. H. Neubert and Antje Ritter and Erin Stolte and Gudrun Albrecht and Hui Jern Loh and Martin Jirka and William L. Fuerst}, journal={Die Pharmazie}, year={1988}, volume={43 12}, pages={848-50} }