Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis.

  title={Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis.},
  author={J. Brouard and N. Knauer and Pierre-Yves Boelle and H. Corvol and A. Henrion-Caude and C. Flamant and F. Br{\'e}mont and B. Delaisi and J. Duhamel and C. Marguet and M. Roussey and Marie-Claude Miesch and K. Chadelat and M. Boul{\'e} and B. Fauroux and F. Ratjen and H. Grasemann and A. Cl{\'e}ment},
  journal={The Journal of infectious diseases},
  volume={191 11},
Recent evidence suggests that genetic polymorphisms that affect the production of interleukin (IL)-10 may play a role in the response to pathogens in cystic fibrosis (CF). The present study was designed to investigate a possible association between alleles carried at position -1082 in the promoter region of the IL-10 gene and clinical data on 378 patients with CF. After adjustment for potential confounding variables, a significant relationship was found between the -1082GG genotype and both… Expand
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