Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse.

@article{Buono2003InfluenceOI,
  title={Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse.},
  author={Chiara Buono and Carolyn E. Come and George Stavrakis and Graham F. Maguire and Philip W. Connelly and Andrew H. Lichtman},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 3},
  pages={454-60}
}
OBJECTIVE The aim of this study was to investigate the influence of interferon-gamma (IFN-gamma) on atherosclerosis in low density lipoprotein receptor (LDLR)-null mice. METHODS AND RESULTS We cross-bred IFN-gamma-deficient mice with LDLR-null mice and analyzed lipoprotein profiles and atherosclerosis in the compound mutant progeny after 8 and 20 weeks on a cholesterol-enriched diet. IFN-gamma deficiency did not affect serum cholesterol levels or lipoprotein profiles, but it did affect the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 93 extracted citations

CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis.

Circulation research • 2016
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…