• Corpus ID: 24308199

Influence of insulin on pharmacokinetics of mannosulfan in rats.

  title={Influence of insulin on pharmacokinetics of mannosulfan in rats.},
  author={Andrzej Danysz and M. Wutkiewicz and Karol Wierzba},
  journal={Archivum immunologiae et therapiae experimentalis},
  volume={27 3},
The purpose of the present study was to investigate the possibilities of potentiation of the antitumor action of mannosulfan after its administration together with insulin. The pharmacokinetics of mannnosulfan were investigated after its administration separately and together with insulin. Concentrations of mannosulfan in the plasma were determined by gas chromatography. Insulin enhanced the rate of absorption of mannosulfan from the peritoneal cavity and prolonged its elimination from the body… 
2 Citations
Insulin impairs the anticonvulsive activity of carbamazepine against maximal electroshock-induced seizures in mice.
It is likely that the inhibitory activity of insulin on the anticonvulsive function of carbamazepine is related not only to the effect of the former on the blood-brain transport of the latter, but also to insulin-induced modulation of the serum concentration of the drug.
Immunity and its role in conventional cancer therapy.
There is at bottom only one genuinely scientific treatment for all diseases, and that is to stimulate the phagocytes… they devour the disease, and the patient recovers.