Influence of insulin on amino acid uptake by lung slices.


We examined the transport of amino acids by rat lung slices using mainly 14C-labeled alpha-aminoisobutyric acid ([14C]AIB) as a nonmetabolized amino acid. We found that [14C]AIB is accumulated by the lung in an energy-dependent fashion against a concentration gradient. The uptake is saturable, stereospecific, and follows Michaelis-Menten kinetics suggesting… (More)