Influence of inositol pyrophosphates on cellular energy dynamics.

@article{Szjgyrt2011InfluenceOI,
  title={Influence of inositol pyrophosphates on cellular energy dynamics.},
  author={Zsolt Sz{\'i}jgy{\'a}rt{\'o} and Assegid Garedew and Cristina Azevedo and Adolfo Saiardi},
  journal={Science},
  year={2011},
  volume={334 6057},
  pages={802-5}
}
With its high-energy phosphate bonds, adenosine triphosphate (ATP) is the main intracellular energy carrier. It also functions in most signaling pathways, as a phosphate donor or a precursor for cyclic adenosine monophosphate. We show here that inositol pyrophosphates participate in the control of intracellular ATP concentration. Yeasts devoid of inositol pyrophosphates have dysfunctional mitochondria but, paradoxically, contain four times as much ATP because of increased glycolysis. We… CONTINUE READING
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