Influence of injectable hyaluronic acid hydrogel degradation behavior on infarction-induced ventricular remodeling.

@article{Tous2011InfluenceOI,
  title={Influence of injectable hyaluronic acid hydrogel degradation behavior on infarction-induced ventricular remodeling.},
  author={Elena Tous and Jamie l. Ifkovits and Kevin J. Koomalsingh and Takashi Shuto and Toru Soeda and Norihiro Kondo and Joseph H. Gorman and Robert C. Gorman and Jason A Burdick},
  journal={Biomacromolecules},
  year={2011},
  volume={12 11},
  pages={4127-35}
}
Increased myocardial wall stress after myocardial infarction (MI) initiates the process of adverse left ventricular (LV) remodeling that is manifest as progressive LV dilatation, loss of global contractile function, and symptomatic heart failure, and recent work has shown that reduction in wall stress through injectable bulking agents attenuates these outcomes. In this study, hyaluronic acid (HA) was functionalized to exhibit controlled and tunable mechanics and degradation once cross-linked… CONTINUE READING

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