Influence of indole carbinols and growth hormone on the metabolism of 4-androstenedione by rat liver microsomes.

@article{Jellinck1993InfluenceOI,
  title={Influence of indole carbinols and growth hormone on the metabolism of 4-androstenedione by rat liver microsomes.},
  author={Peter H Jellinck and Hugh L J Makin and Daniel W. Sepkovic and H. Leon Bradlow},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1993},
  volume={46 6},
  pages={791-8}
}
The effect of indole-3-carbinol (IC), an anticarcinogen present in cruciferous vegetables, to alter the metabolism of 4-androstenedione (AD) by female rat liver microsomes was investigated and compared to that of its main gastric conversion product, diindolylmethane (DIM) as well as other specific cytochrome P450 inducers. DIM was a more potent inducer of… CONTINUE READING