Influence of in vivo interferon treatment on mitogen responsiveness of T-and B-cells is dependent on the mouse genotype.

@article{Huygen1982InfluenceOI,
  title={Influence of in vivo interferon treatment on mitogen responsiveness of T-and B-cells is dependent on the mouse genotype.},
  author={Kris Huygen and Kamiel Palfliet},
  journal={Immunology letters},
  year={1982},
  volume={5 4},
  pages={175-80}
}
Intravenous inoculation of moderate doses of viral interferon (up to 10(4) I.U./mouse) induced subsequent modification of the mitogen responsiveness of T-and B-lymphocytes from the spleen. The modulation, however, was dependent on the mouse genotype. Whereas BALB/c mice demonstrated enhanced T-cell responses (especially to PHA), C57B1/6 mice were generally… CONTINUE READING