Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis.

@article{PascualSalcedo2011InfluenceOI,
  title={Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis.},
  author={Dora Pascual-Salcedo and Chamaida Plasencia and Susana Ramiro and Laura Nu{\~n}o and Gema Bonilla and Daniel Nagore and Ainhoa Ruiz del Agua and Antonio Mart{\'i}nez and Lucien A. Aarden and Emilio Mart{\'i}n-Mola and Alejandro Balsa},
  journal={Rheumatology},
  year={2011},
  volume={50 8},
  pages={1445-52}
}
OBJECTIVE To analyse the clinical relevance of the production of anti-infliximab antibodies (anti-infliximab Abs) in patients with RA undergoing infliximab treatment over a prolonged period of time. METHODS Clinical characteristics, serum trough infliximab and antibody levels were evaluated in 85 RA patients treated with infliximab for a median of 4.42 (interval 0.4-10.2) years. DAS in 28 joints (DAS-28), EULAR response criteria and survival of treatment were assessed at 3 time points (6… CONTINUE READING

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