Influence of immunogenicity on the efficacy of longterm treatment of spondyloarthritis with infliximab.

@article{Plasencia2012InfluenceOI,
  title={Influence of immunogenicity on the efficacy of longterm treatment of spondyloarthritis with infliximab.},
  author={Chamaida Plasencia and Dora Pascual-Salcedo and Laura Nu{\~n}o and Gema Ru{\'i}z Bonilla and Alejandro Dar{\'i}o Villalba and Diana Peiteado and Jes{\'u}s D{\'i}ez and Daniel Nagore and Ainhoa Ruiz del Agua and R. Luque del Moral and Emilio Mart{\'i}n-Mola and Alejandro Balsa},
  journal={Annals of the rheumatic diseases},
  year={2012},
  volume={71 12},
  pages={
          1955-60
        }
}
BACKGROUND Infliximab (IFX) is a monoclonal antibody against tumour necrosis factor α that is effective for treating spondyloarthritis (SpA). However, after initial success of the drug some patients lose responsiveness or develop infusion reactions, which may be related to the development of antibodies against the drug. OBJECTIVE To investigate the clinical relevance of antibodies to infliximab (ATI) formation in patients with SpA undergoing IFX treatment over a prolonged period. METHODS 94… CONTINUE READING
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Immunogenicity of anti-tumour necrosis factor drugs in rheumatic diseases.

  • Clinical and experimental rheumatology
  • 2013
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References

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Infl uence of immunogenicity on the effi cacy of long - term treatment with infl iximab in rheumatoid arthritis

D Pascual-Salcedo, C Plasencia, S Ramiro
  • Rheumatology ( Oxford )
  • 2011

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