• Corpus ID: 25658030

Influence of icodextrin on plasma and dialysate levels of N(epsilon)-(carboxymethyl)lysine and N(epsilon)-(carboxyethyl)lysine.

  title={Influence of icodextrin on plasma and dialysate levels of N(epsilon)-(carboxymethyl)lysine and N(epsilon)-(carboxyethyl)lysine.},
  author={Constantijn J.A.M. Konings and Casper G. Schalkwijk and Frank M van der Sande and Karel M. L. Leunissen and Jeroen P. Kooman},
  journal={Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis},
  volume={25 6},
  • C. Konings, C. Schalkwijk, +2 authors J. Kooman
  • Published 2005
  • Medicine
  • Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
RATIONALE Standard peritoneal glucose solutions may induce the formation of advanced glycation end products (AGEs). Preliminary data suggest that AGE formation may be less with the use of polyglucose solutions (icodextrin). Therefore, we investigated whether the use of icodextrin for the long dwell would result in a reduction in plasma and dialysate levels of the AGE products N(epsilon)-(carboxymethyl) lysine (CML) and N(epsilon)-(carboxyethyl) ysine (CEL). PATIENTS AND METHODS 40 patients… 
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