Influence of hypoxia on excitation and GABAergic inhibition in mature and developing rat neocortex

@article{Luhmann1993InfluenceOH,
  title={Influence of hypoxia on excitation and GABAergic inhibition in mature and developing rat neocortex},
  author={Heiko J. Luhmann and Thomas Kral and Uwe F Heinemann},
  journal={Experimental Brain Research},
  year={1993},
  volume={97},
  pages={209-224}
}
To analyze the functional consequences of hypoxia on the efficacy of intracortical inhibitory mechanisms mediated by gamma-aminobutyric acid (GABA), extra- and intracellular recordings were obtained from rat primary somatosensory cortex in vitro. Hypoxia, induced by transient N2 aeration, caused a decrease in stimulus-evoked inhibitory postsynaptic potentials (IPSPs), followed by a pronounced anoxic depolarization. Upon reoxygenation, the fast (f-) and long-latency (l-) IPSP showed a positive… CONTINUE READING
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Age - dependent susceptibility of rat neocortex to hypoxia studied in vitro ( abstract )

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