Influence of hypoxia on TRAIL-induced apoptosis in tumor cells.

  title={Influence of hypoxia on TRAIL-induced apoptosis in tumor cells.},
  author={Martin Weinmann and Patrizia Marini and Verena Jendrossek and Angelika Betsch and Barbara Goecke and Wilfried Budach and Claus Belka},
  journal={International journal of radiation oncology, biology, physics},
  volume={58 2},
PURPOSE Tumor hypoxia reduces the efficacy of radiotherapy, many types of chemotherapy, and tumor necrosis factor-alpha (TNF-alpha). TRAIL (TNF-alpha-related apoptosis-inducing ligand) is a ligand for death receptors of the TNF superfamily shown to be selectively toxic for tumor cells and thereby a promising antineoplastic tool. The impact of hypoxia on TRAIL-induced apoptosis was examined in this study. METHODS AND MATERIALS Apoptosis induction and growth rates of various tumor cell lines… CONTINUE READING
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