Influence of hypoxia and serotonin on small pulmonary vessels.

  title={Influence of hypoxia and serotonin on small pulmonary vessels.},
  author={Amir Al-Tinawi and Gary S. Krenz and David A. Rickaby and John H. Linehan and Christopher A. Dawson},
  journal={Journal of applied physiology},
  volume={76 1},
X-ray angiograms obtained from isolated perfused dog lungs were used to measure changes in the internal diameter of small intraparenchymal pulmonary arteries (150-1,600 microns) and veins (200-1,000 microns) in response to hypoxia or intra-arterial serotonin [5-hydroxytryptamine (5-HT)] infusion. The diameter changes in response to the two stimuli were measured over a range of stimulus-induced increases (delta Pa) in the total arteriovenous pressure drop. When the resulting delta Pa was small… CONTINUE READING