Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage.

@article{Cernanec2002InfluenceOH,
  title={Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage.},
  author={Julie M Cernanec and Farshid Guilak and J Brice Weinberg and David S. Pisetsky and Beverley Fermor},
  journal={Arthritis and rheumatism},
  year={2002},
  volume={46 4},
  pages={968-75}
}
OBJECTIVE Articular cartilage is an avascular tissue that functions at a lower oxygen tension than do most tissues. With mobilization, arthritic joints may undergo cycles of hypoxia and reoxygenation. The goal of this study was to determine the effects of hypoxia and reoxygenation on cytokine-induced nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production in articular cartilage. METHODS Porcine cartilage explants were incubated at 37 degrees C for 72 hours in either 1% O(2) (hypoxia) or… CONTINUE READING

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