Influence of hypothyroid state on 45Ca(2+) influx and sensitivity of rat uterus to nifedipine and diltiazem.

@article{Parija2001InfluenceOH,
  title={Influence of hypothyroid state on 45Ca(2+) influx and sensitivity of rat uterus to nifedipine and diltiazem.},
  author={S C Parija and Vellanki Raviprakash and Avinash Gopal Telang and Vijai Prakash Varshney and Santosh Kumar Mishra},
  journal={European journal of pharmacology},
  year={2001},
  volume={421 3},
  pages={207-13}
}
The influence of methimazole-induced hypothyroidism on spontaneous rhythmic contractions and Ca2+ channel function of rat uterus was examined. Hypothyroidism significantly reduced the amplitude and frequency of spontaneous rhythmic contractions. Nifedipine (10(-12)-10(-6) M) and diltiazem (10(-9)-10(-4) M) caused concentration-related inhibition of the myogenic responses of the oestrogenised rat uterus obtained from both eu- and hypothyroid rats. However, nifedipine was less potent (IC(50); 5.4… CONTINUE READING