Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress.

@article{Girotti2013InfluenceOH,
  title={Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress.},
  author={Milena Girotti and Jennifer J. Donegan and David A Morilak},
  journal={Psychoneuroendocrinology},
  year={2013},
  volume={38 7},
  pages={1158-69}
}
Abnormal basal activity and stress-evoked reactivity of the hypothalamic-pituitary-adrenal (HPA) axis are often seen in depression, implicating HPA axis dysfunction as a potentially causative or exacerbating factor. Chronic stress is also a factor in depression, but it is not known what may underlie the shift from adaptive to maladaptive HPA activity over the course of chronic stress. Interleukin 6 (IL-6), a stress-inducible cytokine that signals through gp130 and IL-6Rα receptors to activate… CONTINUE READING
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Determining the role of hypothalamic IL-6 in sensitization of the rat HPA axis by exposure to chronic cold stress

  • M. Girotti, J. J. Donegan, D. A. Morilak
  • Soc. Neurosci. Abstr
  • 2011
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