Influence of hydroxypropyl‐β‐cyclodextrin on photo‐induced free radical production by the sunscreen agent, butyl‐methoxydibenzoylmethane

  title={Influence of hydroxypropyl‐$\beta$‐cyclodextrin on photo‐induced free radical production by the sunscreen agent, butyl‐methoxydibenzoylmethane},
  author={Santo Scalia and Silvia Simeoni and Andrea Barbieri and Silvana Sostero},
  journal={Journal of Pharmacy and Pharmacology},
The aim of the study was to investigate the effect of hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) on the photo‐induced production of free radicals by the sunscreen agent, butyl‐methoxydibenzoylmethane (BMDBM). Spin‐trapping/electron paramagnetic resonance spectroscopy was used to evaluate the formation of radicals and the extent of BMDBM photodegradation was measured by high‐performance liquid chromatography. The stable 2,2,6,6‐tetramethylpiperidine‐1‐oxyl, nitroxide radical (TEMPO) was used as spin… Expand
Influence of hydroxypropyl-beta-cyclodextrin on transdermal penetration and photostability of avobenzone.
  • J. Yang, Cody J Wiley, D. Godwin, L. Felton
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2008
In vivo, inclusion of HPCD in sunscreen formulations may enhance photoprotection by reducing both skin penetration and photodecomposition of UV absorbers, as evidenced by the lowest extent of sunburn cell formation and edema induction. Expand
Studies on the preparation and photostability of avobenzone and (2-hydroxy)propyl-β-cyclodextrin inclusion complex
Abstract The inclusion complex of avobenzone and (2-hydroxy)propyl-β-cyclodextrin (2-HP-β-CD) was prepared successfully. The effects of the inclusion behavior of avobenzone with 2-HP-β-CD wereExpand
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The water-soluble inclusion complexes of curcumin, 2-ethylhexyl-4-methoxycinnamate (EHMC) and 4-tert-butyl-4′-methoxydibenzoylmethane (DBM) with gamma-cyclodextrin polymer (pyCD) were successfullyExpand
Influence of cyclodextrins on in vitro human skin absorption of the sunscreen, butyl-methoxydibenzoylmethane.
The decreased BM-DBM retention in the epidermal region achieved by SBE7-beta-CD limits direct contact of the sunscreen and of its reactive photolytic products with the skin viable tissues. Expand
Co-loading of a Photostabilizer with the Sunscreen Agent, Butyl Methoxydibenzoylmethane in Solid Lipid Microparticles
The sunscreen agent, butyl methoxydibenzoylmethane (BMDBM), one of the most widely used UV-A filter, undergoes decomposition under sunlight exposure, which is a limiting factor on its overallExpand
Reactive oxygen species produced upon photoexcitation of sunscreens containing titanium dioxide (an EPR study).
The continuous in situ irradiation of titanium dioxide powder, recommended for cosmetic application, investigated in different solvents resulted in the generation of oxygen-centered reactive radical species (superoxide anion radical, hydroxyl and alkoxyl radicals). Expand
Microencapsulation of a cyclodextrin complex of the UV filter, butyl methoxydibenzoylmethane: in vivo skin penetration studies.
The reduced BMDBM percutaneous penetration attained by the latter system should enhance the UV filter efficacy and limit potential toxicological risks. Expand
Photostabilization Effect of Quercetin on the UV Filter Combination, Butyl Methoxydibenzoylmethane–Octyl Methoxycinnamate
Comparison photodegradation studies demonstrated that quercetin was much more effective and at a lower concentration than commonly used stabilizer (octocrylene) and antioxidants (vitamin E, butylated hydroxyanisole). Expand
Encapsulation in lipospheres of the complex between butyl methoxydibenzoylmethane and hydroxypropyl-beta-cyclodextrin.
Investigation of the incorporation into lipospheres of the complex between hydroxypropyl-beta-cyclodextrin and the sunscreen agent, butyl methoxydibenzoylmethane found that incorporation in lipid microparticles of BMDBM in the cyclodesxtrin complex form is more effective in enhancing the sunscreen photostability than the complex alone or the liposphere-entrapped free BM DBM. Expand
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Abstract The interaction between the sunscreen, butyl-methoxydibenzoylmethane (BM-DBM), and parent and modified α-, β- or γ-cyclodextrins was investigated in water by phase-solubility analysis. AmongExpand
EPR properties of two new cyclic phosphinylhydrazyl radicals and of their inclusion complexes with cyclodextrins
Two phosphorus-containing hydrazines, namely morpholin-4-ylphosphoramidic acid diethyl ester and (2,2,6,6-tetramethylpiperidin-1-yl)phosphoryl ester, have been synthesized and the corresponding hydrazyl radicals have been obtained, by in situ oxidation, and their properties have been investigated by EPR spectroscopy. Expand
Increased oxidative modification of albumin when illuminated in vitro in the presence of a common sunscreen ingredient: protection by nitroxide radicals.
The results obtained corroborate the fact that Parsol 1789 generates free radicals upon illumination and that these are, most probably, responsible for the protein damage observed under the conditions used in the system. Expand
Nitroxide radicals protect DNA from damage when illuminated in vitro in the presence of dibenzoylmethane and a common sunscreen ingredient.
Indolinonic nitroxides and the piperidines TEMPO and TEMPOL are compared for their ability to inhibit strand breaks inflicted on DNA when it is illuminated in vitro in the presence of dibenzoylmethane and a relative, Parsol 1789, used as a UVA-absorbing sunscreen. Expand
Photodecomposition of several compounds commonly used as sunscreen agents
Abstract The photolysis reactions of three compounds commonly used as a sunscreen agents, Parsol 1789 (1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-1,3- propanedione), OxybenzoneExpand
Photoallergic Contact Dermatitis due to Combined UVB (4-Methylbenzylidene Camphor/Octyl Methoxycinnamate) and UVA (Benzophenone-3/Butyl Methoxydibenzoylmethane) Absorber Sensitization
In a 71-year-old male Caucasian patient with persistent eczema on light-exposed skin, photocontact allergy was demonstrated to the UV filter substances 4-methylbenzylidene camphor (UVB), octylExpand
Photochemistry of dibenzoyl methane UVA filters Part 1
Abstract Two dibenzoyl methane derivatives, 4-isopropyldibenzoyl methane (I-DBM) and 4-t-butyl-3′-methoxydibenzoyl methand (BM-DBM), have been found to be photolabile towards UVA light in non-polarExpand
In Vitro Assessment of Sunscreen Photostability: The Effect of Radiation Source, Sunscreen Application Thickness and Substrate
Transmission spectroscopy, with either a quartz or a human epidermis substrate, can be used successfully to compare the photostabilities of different sunscreen products, and the ranking of the four products in terms of their photostability was the same for both substrates. Expand
Changes in ultraviolet absorption of sunscreens after ultraviolet irradiation.
This study including gas chromatography and mass spectrometry analysis indicates that some of the photoactive organic species commonly used today in sunscreens are unstable following ultraviolet irradiation. Expand
Photocontact allergy to 4‐tert,buty‐4′‐methoxy‐dibenzoylmethane (Parsol 1789)
It is advisable for patients who are to undergo patch testing to be off loratadine to enable an evaluation that reflects their true sensitization state, and reduced reactions under the influence of oral antihistamine therapy could even be interpreted as negative. Expand