Influence of human haptoglobin polymorphism on oxidative stress induced by free hemoglobin on red blood cells.

@article{Guye2006InfluenceOH,
  title={Influence of human haptoglobin polymorphism on oxidative stress induced by free hemoglobin on red blood cells.},
  author={Papa Madi{\`e}ye Gu{\'e}ye and Nicole M. Glasser and Georges F{\'e}rard and J M Lessinger},
  journal={Clinical chemistry and laboratory medicine},
  year={2006},
  volume={44 5},
  pages={542-7}
}
BACKGROUND An in vitro study was conducted to determine whether haptoglobin phenotypes differed in their protective effect against oxidative stress induced by extracellular hemoglobin on red blood cells. METHODS Conjugated dienes and thiobarbituric acid-reactive substances (TBARS) were determined in human red blood cell membranes in the presence of hemoglobin and various concentrations of each type of purified haptoglobin. In addition, the release of K+ and lactate dehydrogenase from red… CONTINUE READING

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