Influence of housing conditions on the acquisition of intravenous heroin and cocaine self-administration in rats

@article{Bozarth1989InfluenceOH,
  title={Influence of housing conditions on the acquisition of intravenous heroin and cocaine self-administration in rats},
  author={Michael A. Bozarth and Aileen Murray and Roy A. Wise},
  journal={Pharmacology Biochemistry and Behavior},
  year={1989},
  volume={33},
  pages={903-907}
}
Group-housed and individually housed rats were tested for the acquisition of a lever-pressing response reinforced by intravenous heroin or cocaine; animals in each housing condition quickly learned to self-administer drug. In the first experiment the isolated rats learned to self-administer heroin earlier than the group-housed animals, but the two groups self-administered similar levels of heroin by the fifth week of testing. In the second experiment cocaine self-administration was learned with… Expand

Topics from this paper

Isolation rearing enhances the locomotor response to cocaine and a novel environment, but impairs the intravenous self-administration of cocaine
TLDR
Male Lister hooded rats were raised from weaning either alone (isolation reared) or in groups of five (socially reared controls) and their interactions with the mesoaccumbens dopamine projection were discussed with reference to dysfunctional cortico-limbic-striatal systems. Expand
Enhanced cocaine self-administration in adult rats with adolescent isolation experience
TLDR
It is shown that rats with adolescent isolation experience have enhanced cocaine self-administration behavior, and intervals of inter-reinforcement for cocaine in isolated rats were significantly shorter as compared with grouped rats. Expand
Differential effects of an early housing manipulation on cocaine-induced activity and self-administration in laboratory rats
TLDR
The present investigation suggests that, while the early housing manipulation produced a differential sensitivity in rats to the stimulant properties of cocaine, the same manipulation failed to alter the sensitivity of Rats to the reinforcing properties of Cocaine as assessed through self-administration. Expand
Pair housing differentially affects motivation to self-administer cocaine in male and female rats
TLDR
The motivation to take cocaine escalates in females but not males, and pair-housing of females attenuates this escalation, which was attenuated by pair housing of females. Expand
Isolation rearing impairs the reinforcing efficacy of intravenous cocaine or intra-accumbensd-amphetamine: impaired response to intra-accumbens D1 and D2/D3 dopamine receptor antagonists
TLDR
Male Lister hooded rats were raised from weaning either alone (isolation reared) or in groups of five (socially reared controls) and the functioning of cortico-limbicstriatal systems, with particular reference to the mesoaccumbens dopamine projection was discussed. Expand
Intravenous Cocaine Self-Administration in Mice Lacking 5-HT1B Receptors
TLDR
The results suggest that the 5-HT1B receptors may be implicated in the propensity to self-administer cocaine, but other mechanisms might be involved in the maintenance of cocaine self-administration. Expand
Nicotine self-administration in rats
TLDR
This model of nicotine self-administration provides a reliable alternative to experimenter-Administration models for examining the effects of nicotine. Expand
Differential responsiveness to cocaine in C57BL/6J and DBA/2J mice
TLDR
Cocaine concentration in the brains of DBA/2J and C57BL/6J mice failed to differ following IP injection, suggesting that distribution factors were not involved in the differential responses to cocaine. Expand
Effect of social housing and oxytocin on the motivation to self-administer methamphetamine in female rats
TLDR
The data show that social housing attenuates escalation of Meth intake and reinstatement of METH seeking in female rats, and that chronic OT treatment can reduce motivation for METH. Expand
Effects of early environmental experience on self-administration of amphetamine and barbital
TLDR
Individual differences in rates of initiation, choice of abusing agent, and maintenance of drug self-administration may be partially determined by pre-existing differences in central nervous system functioning due to early experiences. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 15 REFERENCES
Effect of early and later colony housing on oral ingestion of morphine in rats
Male and female rats were raised from weaning either in isolation or in a large colony. At 65 days of age, half the rats in each environment were moved to the other. At 80 days, the animals wereExpand
Intravenous Self-Administration: Response Rates, the Effects of Pharmacological Challenges, and Drug Preference
TLDR
Intravenous self-administration preparations, utilizing a chronic indwelling catheter, have been developed for the rat, rhesus monkey, dog, squirrel monkey, pig, baboon, cat, and mouse which are considered to be reliable predictors of the abuse potential of drugs. Expand
Endogenous opioids and social behavior
TLDR
In young rats tested in social learning situations, morphine delays and naloxone hasten extinction, consistent with the proposition that brain opioids modulate social emotions and behaviors. Expand
Effects of morphine and naloxone on separation distress and approach attachment: Evidence for opiate mediation of social affect
TLDR
The hypothesis that an endorphin-based addiction-like process may underlie the maintenance of social attachments, and that separation distress may reflect a state of endogenous "endorphin withdrawal", is supported. Expand
Neural substrates of opiate reinforcement
  • M. Bozarth, R. Wise
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1983
TLDR
A major component of opiate reward is derived from a drug action in the ventral tegmental area, and it is theoretically viable that opiates derive their reinforcing impact from a combination of positive and negative reinforcement processes. Expand
The biology of social attachments: opiates alleviate separation distress.
TLDR
The possibility is entertained that brain opiates may function to control the intensity of emotions arising from social separation and parallels between the biological nature of narcotic addiction and the formation of social bonds are discussed. Expand
Brain substrates for reinforcement and drug self-administration.
TLDR
The substrate mediating rewarding actions of opiates and psychomotor stimulants also mediates the rewarding action of more natural rewards like food and water, which suggests that the brain has specialized circuitry for mediation of reward. Expand
Action of drugs of abuse on brain reward systems: An update with specific attention to opiates
TLDR
In addressing the role that the substrate of brain stimulation reward might play in drug abuse, Wise speculated that one possible mechanism of opiate, ethanol, barbiturate or benzodiazepine reward might involve a specified disinhibition of the dopaminergic element. Expand
Neural basis of psychomotor stimulant and opiate reward: Evidence suggesting the involvement of a common dopaminergic system
  • M. Bozarth
  • Medicine, Biology
  • Behavioural Brain Research
  • 1986
TLDR
Data are reviewed that suggest a common neural system may be involved in the rewarding properties of psychomotor stimulant and opiate drugs, and its ability to activate the ventral tegmental dopamine system appears to make an important contribution to their net reinforcing impact. Expand
Ascending endorphin inhibition of distress vocalization.
TLDR
Evidence is provided for ascending endorphin-mediated inhibition of excitatory forebrain sites for distress vocalizations in adult guinea pigs. Expand
...
1
2
...