Influence of hormones and growth factors on lens protein composition: the effect of dexamethasone and PDGF-AA.

Abstract

PURPOSE To investigate the effect of hormones and ocular growth factors on the expression of alpha-, beta-, and gamma-crystallins in rat lens epithelial and fiber cells. METHODS PDGF-AA, EGF, NGF, M-CSF, BMP-2, BMP-4, dexamethasone, and estrogen were tested for their ability to alter the spectrum of crystallins in explanted newborn rat lens epithelial… (More)

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