Influence of histological type, smoking history and chemotherapy on survival after first-line therapy in patients with advanced non-small cell lung cancer.

@article{Itaya2007InfluenceOH,
  title={Influence of histological type, smoking history and chemotherapy on survival after first-line therapy in patients with advanced non-small cell lung cancer.},
  author={Toru Itaya and Nobuyuki Yamaoto and Masahiko Ando and Masako Ebisawa and Yukiko Nakamura and Haruyasu Murakami and Gyo Asai and Masahiro Endo and Toshiaki Takahashi},
  journal={Cancer science},
  year={2007},
  volume={98 2},
  pages={226-30}
}
The usual primary endpoint in clinical trials for first-line chemotherapy in advanced non-small cell lung cancer is overall survival. Second-line chemotherapy can also prolong overall survival. Non-smoking history has been associated with a treatment effect for epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) versus placebo for overall survival. We performed a retrospective analysis to identify prognostic factors for progression-free survival and overall survival in… CONTINUE READING