Influence of high altitude on cerebrovascular and ventilatory responsiveness to CO2.

@article{Fan2010InfluenceOH,
  title={Influence of high altitude on cerebrovascular and ventilatory responsiveness to CO2.},
  author={J L Fan and Keith R. Burgess and Riche Basnyat and Kate Nicole Thomas and Karen Peebles and Samuel J E Lucas and Rebekah A I Lucas and Joseph Donnelly and James D Cotter and Philip N. Ainslie},
  journal={The Journal of physiology},
  year={2010},
  volume={588 Pt 3},
  pages={539-49}
}
An altered acid-base balance following ascent to high altitude has been well established. Such changes in pH buffering could potentially account for the observed increase in ventilatory CO(2) sensitivity at high altitude. Likewise, if [H(+)] is the main determinant of cerebrovascular tone, then an alteration in pH buffering may also enhance the cerebral blood flow (CBF) responsiveness to CO(2) (termed cerebrovascular CO(2) reactivity). However, the effect altered acid-base balance associated… CONTINUE READING
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Acid-base balance in cerebral fluids. In: Handbook of Physiology. The Respiratory System. Control of Breathing

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  • Bethesda, MD: Am Physiol Soc,
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