Influence of hexachlorocyclohexane on phosphoinositides in rat erythrocyte membranes and brain.

@article{Agrawal1995InfluenceOH,
  title={Influence of hexachlorocyclohexane on phosphoinositides in rat erythrocyte membranes and brain.},
  author={Deepa Agrawal and A. Subramoniam and F Afaq},
  journal={Toxicology},
  year={1995},
  volume={95 1-3},
  pages={135-40}
}
Single exposure of rats to hexachlorocyclohexane (100 mg/kg) did not cause any significant change in phosphoinositide levels in rat erythrocyte membrane and cerebrum (fore brain) 2 or 24 h after exposure. However, the phosphoinositide turnover and generation of second messengers from phosphoinositides were increased in the treated erythrocyte membranes as judged from a marked increase in the incorporation of [2-3H]inositol into phosphoinositides 24 h after the treatment. A significant decrease… CONTINUE READING