Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease.

@article{Sumi2003InfluenceOH,
  title={Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease.},
  author={Hajime Sumi and Osamu Yokosuka and Naohiko Seki and Makoto Arai and Fumio Imazeki and Tomoko Kurihara and Tatsuo Kanda and Kenichi Fukai and Masaki Kato and Hiromitsu Saisho},
  journal={Hepatology},
  year={2003},
  volume={37 1},
  pages={19-26}
}
To investigate the hepatitis B virus (HBV) genotype-related differences in the progression of liver disease, 585 patients with chronic HBV infection including 258 with histologically verified chronic liver disease (CLD) and 74 with hepatocellular carcinoma (HCC) were examined. The mean ages of both patients with advanced fibrosis (F3 or F4) and with HCC were significantly older in genotype B than in genotype C patients (P =.018, P =.024, respectively). Both the hepatitis B e antigen (HBeAg… CONTINUE READING