Influence of hepatitis B virus genotypes on the intra- and extracellular expression of viral DNA and antigens.

@article{Sugiyama2006InfluenceOH,
  title={Influence of hepatitis B virus genotypes on the intra- and extracellular expression of viral DNA and antigens.},
  author={M Sugiyama and Yasuhito Tanaka and Takanobu Kato and Etsuro Orito and Kiyoaki Ito and Subrat kumar Acharya and Robert Gish and Anna Kramvis and Takashi L Shimada and Namiki Izumi and Masahiko Kaito and Yuzo Miyakawa and Masashi Mizokami},
  journal={Hepatology},
  year={2006},
  volume={44 4},
  pages={915-24}
}
Various genotypes of the hepatitis B virus (HBV) induce liver disease of distinct severity, but the underlying virological differences are not well defined. Huh7 cells were transfected with plasmids carrying 1.24-fold the HBV genome of different genotypes/subgenotypes (2 strains each for Aa/A1, Ae/A2, Ba/B2 and D; 3 each for Bj/B1 and C). HBV DNA levels in cell lysates, determined by Southern hybridization, were the highest for C followed by Bj/Ba and D/Ae (P < .01), and the lowest for Aa (P… CONTINUE READING
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