Influence of heparin and dendrimers on the aggregation of two amyloid peptides related to Alzheimer's and prion diseases.

@article{Klajnert2006InfluenceOH,
  title={Influence of heparin and dendrimers on the aggregation of two amyloid peptides related to Alzheimer's and prion diseases.},
  author={Barbara Klajnert and Marta Cortijo-Arellano and Maria J Bryszewska and Josep Roca Cladera},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={339 2},
  pages={
          577-82
        }
}
Amyloid plaques composed of proteinaceous aggregates are commonly found in brains affected by Alzheimer's disease and spongiform encephalopaties. A structural homology has been recently described for the Alzheimer's peptide Abeta1-28 and the segment of the prion protein Prp185-208. In the present paper, further elements in common are reported: the aggregation processes are in both cases enhanced by the model glucosaminoglycan heparin and dendrimers can modulate the aggregation process by… CONTINUE READING
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