Influence of hemodynamic forces on vascular endothelial function. In vitro studies of shear stress and pinocytosis in bovine aortic cells.

@article{Davies1984InfluenceOH,
  title={Influence of hemodynamic forces on vascular endothelial function. In vitro studies of shear stress and pinocytosis in bovine aortic cells.},
  author={Peter Francis Davies and C. Forbes Dewey and Steven R. Bussolari and Ethel J. Gordon and Michael A. Gimbrone},
  journal={The Journal of clinical investigation},
  year={1984},
  volume={73 4},
  pages={1121-9}
}
The relationships between fluid shear stress, a physiologically relevant mechanical force in the circulatory system, and pinocytosis (fluid-phase endocytosis) were investigated in cultured bovine aortic endothelial cells using a specially designed apparatus. Continuous exposure to steady shear stresses (1-15 dyn/cm2) in laminar flow stimulated time- and amplitude-dependent increases in pinocytotic rate which returned to control levels after several hours. After 48 h continuous exposure to… CONTINUE READING
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