Influence of growth hormone receptor d3 and full-length isoforms on biochemical treatment outcomes in acromegaly.

@article{Bianchi2009InfluenceOG,
  title={Influence of growth hormone receptor d3 and full-length isoforms on biochemical treatment outcomes in acromegaly.},
  author={Antonio Bianchi and Andrea Giustina and Vincenzo Cimino and Roberto Pola and Flavia Angelini and Alfredo Pontecorvi and Laura de Marinis},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 6},
  pages={2015-22}
}
CONTEXT In acromegaly, a discrepancy between what are defined as "normal" levels of GH and IGF-I for every given patient is observed in up to 35% of subjects at diagnosis and during the follow-up. OBJECTIVE The aim of the study was to evaluate the impact of GH receptor (GHR) polymorphism on the biochemical assessment of the treatment of acromegaly and on prevalence of discordant levels of GH and IGF-I. SETTING The study was performed in an institutional referral center at a tertiary care… CONTINUE READING

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