Influence of group A streptococcal acid glycoprotein on expression of major virulence factors and internalization by epithelial cells.

@article{Marouni2003InfluenceOG,
  title={Influence of group A streptococcal acid glycoprotein on expression of major virulence factors and internalization by epithelial cells.},
  author={Mehran J Marouni and Edmund Ziomek and Shlomo Sela},
  journal={Microbial pathogenesis},
  year={2003},
  volume={35 2},
  pages={63-72}
}
A single transposon insertion upstream to the open-reading-frame identified as the streptococcal acid glycoprotein (sagp) gene rendered a Tn916 isolate of Streptococcus pyogenes with elevated susceptibility to internalization by the epithelial cells. The role of SAGP in S. pyogenes internalization was further studied using isogenic mutant containing an in-frame deletion within the sagp gene. The sagp mutant displayed slower growth-rate and showed 5-fold higher internalization efficiency than… CONTINUE READING