Influence of gonadotropin-releasing hormone on castration-induced 'depression' in mice: a behavioral and binding study.

@article{Bernardi1990InfluenceOG,
  title={Influence of gonadotropin-releasing hormone on castration-induced 'depression' in mice: a behavioral and binding study.},
  author={Mara Bernardi and Maurizio Sandrini and Anna Valeria Vergoni and D Marrama and Simonetta Tagliavini and Alfio Bertolini},
  journal={European journal of pharmacology},
  year={1990},
  volume={187 3},
  pages={501-6}
}
Long-term (33-35 days) castration caused a significant increase in the duration of immobility of male and female mice in the tail suspension test (an animal model of depression), and a significant decrease in the maximum number (Bmax) of [3H]imipramine binding sites in the cerebral cortex of male mice. In the tail suspension test, gonadotropin-releasing hormone (GnRH), s.c. injected 3 times at 3-h intervals at doses of 0.2, 2 or 20 micrograms/kg, did not significantly modify the duration of… CONTINUE READING