Influence of glycosylation on diagnostic and prognostic accuracy of N-terminal pro-B-type natriuretic peptide in acute dyspnea: data from the Akershus Cardiac Examination 2 Study.

@article{Rsj2015InfluenceOG,
  title={Influence of glycosylation on diagnostic and prognostic accuracy of N-terminal pro-B-type natriuretic peptide in acute dyspnea: data from the Akershus Cardiac Examination 2 Study.},
  author={Helge R{\o}sj{\o} and Mai Britt Dahl and Marit J{\o}rgensen and Ragnhild R{\o}ysland and Jon Brynildsen and Alessandro Cataliotti and Gregory A. Christensen and Arne Didrik H{\o}iseth and Tor-Arne Hagve and Torbj{\o}rn Omland},
  journal={Clinical chemistry},
  year={2015},
  volume={61 8},
  pages={
          1087-97
        }
}
BACKGROUND The N-terminal part of pro-B-type natriuretic peptide (NT-proBNP) is glycosylated, but whether glycosylation influences the diagnostic and prognostic accuracy of NT-proBNP measurements is not known. METHODS We measured NT-proBNP concentrations of 309 patients with acute dyspnea by use of standard EDTA tubes and EDTA tubes pretreated with deglycosylation enzymes. The primary cause of dyspnea was classified as heart failure (HF) or non-HF, and the diagnosis was adjudicated by 2… CONTINUE READING
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