Influence of glutathione on the oxidation of 1-methyl-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline: chemistry of potential relevance to the addictive and neurodegenerative consequences of ethanol use.

@article{Han1996InfluenceOG,
  title={Influence of glutathione on the oxidation of 1-methyl-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline: chemistry of potential relevance to the addictive and neurodegenerative consequences of ethanol use.},
  author={Qingguo Han and Glenn Dryhurst},
  journal={Journal of medicinal chemistry},
  year={1996},
  volume={39 7},
  pages={
          1494-508
        }
}
  • Qingguo Han, Glenn Dryhurst
  • Published 1996
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • Recent evidence suggests that intraneuronal metabolism of ethanol by catalase/H2O2 and an ethanol-inducible form of cytochrome P450 together generate acetaldehyde and oxygen radicals including the hydroxyl radical (HO.). Within the cytoplasm of serotonergic neurons, these metabolic processes would thus provide acetaldehyde, which would react with unbound 5-hydroxytryptamine (5-HT) to give 1-methyl-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline (1), known to be formed at elevated levels in the… CONTINUE READING